Background: Alveolar bone defects in children still have a high incidence. Conventional bone graft technique that has been used as a defect therapy is still not effective. so new techniques with tissue engineering approach are needed. Bone Morphogenetic Protein 4 (BMP4) as one of the indicators of osteogenic differentiation has not been widely studied. https://parisnaturalfoodes.shop/product-category/gaba-chewable/