To investigate the potential role of apple polyphenol extract (APE) in the prevention and alleviation of circadian rhythm disturbances. eighty male C57BL/6 mice fed a high-fat diet (HFD) were randomized into four groups: 24 h ad libitum feeding (AL). 12 h restricted nighttime feeding (NF) or daytime feeding (DF). and daytime feeding with APE intragastric administration (DF-APE). https://foldlyers.shop/product-category/switchers/