Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by accumulation of fragmented insoluble TDP-43 and loss of TDP-43 from the nucleus. Increased expression of exogenous TARDBP (encoding TDP-43) induces TDP-43 pathology and cytotoxicity. suggesting the involvement of aberrant expression of TDP-43 in the pathogenesis of ALS. In normal conditions. https://www.spidertattooz.com/Metabo-HPT-NT1865DMASTM-18V-MV-15-Gauge-Brushless-Cordless-Angled-Finish-Nailer/