Ferroptosis is a type of programmed cell death resulting from iron overload-dependent lipid peroxidation. and could be promoted by activating transcription factor 3 (ATF3). SIRT1 is an enzyme accounting for removing acetylated lysine residues from target proteins by consuming NAD+. but its role remains elusive in ferroptosis and activating ATF3. https://www.roneverhart.com/Oakley-Sutro/